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The
Role of Vitamin E in the Prevention of Heart
Disease David H. Emmert,
MD; Jeffrey T. Kirchner, DO
Data from
the 1970s first suggested that vitamin E may be
effective in decreasing mortality from
cardiovascular disease. As the understanding of
the antioxidant effect of this vitamin evolved,
researchers began to further study the biologic
effects of vitamin E. In vitro studies have
shown vitamin E to have several potentially
cardio protective effects, including
antagonizing the oxidation of low-density
lipoproteins, inhibiting platelet aggregation
and adhesion, preventing smooth muscle
proliferation, and preserving normal coronary
dilation. Several prospective studies, including
the US Nurses' Health Study and the US Health
Professionals' Follow-up Study, found a 34% and
39% reduction, respectively, in the risk of
having a cardiac event for those taking vitamin
E supplements. The Iowa Women's Health Study
found a 47% reduction in cardiac mortality.
Results of randomized, controlled clinical
trials have not found consistent benefit,
however. The best known of these trials, the
Cambridge Heart Antioxidant Study, found a 47%
reduction in fatal and nonfatal myocardial
infarction in patients with proven coronary
atherosclerosis who were given 400 or 800 IU of
vitamin E daily. There was, however, no effect
on mortality. While emerging and promising data
suggest the potential benefit of vitamin E for
high-risk cardiac patients, physicians should be
alert to the results of randomized, controlled
clinical trials already in
progress.
Arch Fam Med.
1999;8:537-542
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There are 90 nutrients essential
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| Updates
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Articles, Studies and Publications
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Role of Vitamin E in the
Prevention of Heart Disease
Journal of
American Medical Association (JAMA) Nov/Dec
1999
The Little Mineral that
Could (Calcium and colon cancer, osteoporosis,
high blood pressure, PMS, etc.)
Newsweek,
Spring/Summer 1999
Recommendations for Vitamin
C Intake (Studies show not enough in diet, FDA to
low)
Journal of
American Medical Association (JAMA)
12/08/99
Scarcity of Vitamins and
Minerals in Our Foods
Omaha
World Herald 01/29/00
Selenium and Cancer
Prevention
Cancer
Institute, Chinese Academy of Medical
Sciences
International Epidemiology
Institute
British
Journal of Urology
Biological
Trace Element Research
Malabsorption
and DeficiencyDisease
Longevity
Institute
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